Scaffold Fabrication for Drug Delivery System Using Layered Manufacturing Methods

To fabricate functional shape of drug delivery system (DDS), various processes are used. In this research, based on layered manufacturing, two different processes of 1) replication and 2) direct deposition were used to fabricate scaffold type implantable DDS. For replication process, hot embossing process for fabrication of patterned layers and bonding for construction of three-dimensional shape were used. As a direct deposition process, nano composite deposition system (NCDS) was used. Various scaffolds were fabricated with different filament size, pore size, and shape. It is observed that the scaffold type of implantable DDS is more stable than non-porous DDS through the in vivo test.