Rethinking the Term "Pi-Stacking"

dc.contributor.utaustinauthorMartinez, Chelsea R.en_US
dc.contributor.utaustinauthorIverson, Brent L.en_US
dc.creatorMartinez, Chelsea R.en_US
dc.creatorIverson, Brent L.en_US
dc.date.accessioned2016-09-23T18:05:01Z
dc.date.available2016-09-23T18:05:01Z
dc.date.issued2012-04en_US
dc.description.abstractIt has become common to reference "pi-stacking" forces or "pi-pi interactions" when describing the interactions between neighbouring aromatic rings. Here, we review experimental and theoretical literature across several fields and conclude that the terms "pi-stacking" and "pi-pi interactions" do not accurately describe the forces that drive association between aromatic molecules of the types most commonly studied in chemistry or biology laboratories. We therefore propose that these terms are misleading and should no longer be used. Even without these terms, electrostatic considerations relating to polarized pi systems, as described by Hunter and Sanders, have provided a good qualitative starting place for predicting and understanding the interactions between aromatics for almost two decades. More recent work, however, is revealing that direct electrostatic interactions between polarized atoms of substituents as well as solvation/desolvation effects in strongly interacting solvents must also be considered and even dominate in many circumstances.en_US
dc.description.departmentChemistryen_US
dc.description.sponsorshipen_US
dc.identifierdoi:10.15781/T2XW47X6T
dc.identifier.citationMartinez, Chelsea R., and Brent L. Iverson. "Rethinking the term “pi-stacking”." Chemical Science 3, no. 7 (Apr., 2012): 2191-2201.en_US
dc.identifier.doi10.1039/c2sc20045gen_US
dc.identifier.issn2041-6520en_US
dc.identifier.urihttp://hdl.handle.net/2152/41033
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.relation.ispartofserialChemical Scienceen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.rights.restrictionOpenen_US
dc.subjectaromatic-aromatic interactionsen_US
dc.subjectside-chain interactionsen_US
dc.subjectmolecularen_US
dc.subjecttorsion balanceen_US
dc.subjectdna-baseen_US
dc.subjectab-initioen_US
dc.subjectsupramolecular hydrogelsen_US
dc.subjectsynthetic receptorsen_US
dc.subjectaqueous-solutionen_US
dc.subjecthetero-duplexesen_US
dc.subjectnear-sequenceen_US
dc.subjectchemistry, multidisciplinaryen_US
dc.titleRethinking the Term "Pi-Stacking"en_US
dc.typeArticleen_US

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