Reduced sp.sup.3 texaphyrins

dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorJonathan L. Sessler
dc.creatorGregory W. Hemmi
dc.creatorTarak D. Mody
dc.date.accessioned2019-10-23T14:31:20Z
dc.date.available2019-10-23T14:31:20Z
dc.date.filed1994-07-26
dc.date.issued1996-04-02
dc.description.abstractThe present invention involves water soluble hydroxy-substituted texaphyrins retaining lipophilicity, the synthesis of such compounds and their uses. These expanded porphyrin-like macrocycles are efficient chelators of divalent and trivalent metal ions. Various metal (e.g., transition, main group, and lanthanide) complexes of the hydroxy-substituted texaphyrin derivatives of the present invention have unusual water solubility and stability. They absorb light strongly in a physiologically important region (i.e. 690-880 nm). They have enhanced relaxivity and therefore are useful in magnetic resonance imaging. They form long-lived triplet states in high yield and act as photosensitizers for the generation of singlet oxygen. Thus, they are useful for inactivation or destruction of human immunodeficiency virus (HIV-1), mononuclear or other cells infected with such virus as well as tumor cells. They are water soluble, yet they retain sufficient lipophilicity so as to have greater affinity for lipid rich areas such as atheroma and tumors. They may be used for magnetic resonance imaging followed by photodynamic tumor therapy in the treatment of atheroma and tumors. These properties, coupled with their high chemical stability and appreciable solubility in water, add to their usefulness.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber8280351
dc.identifier.patentnumber5504205
dc.identifier.urihttps://hdl.handle.net/2152/76608
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3697
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K51/0485
dc.subject.cpcA61K41/0009
dc.subject.cpcA61K41/0038
dc.subject.cpcA61K41/0076
dc.subject.cpcA61K47/546
dc.subject.cpcA61K49/0021
dc.subject.cpcA61K49/0036
dc.subject.cpcA61K49/0058
dc.subject.cpcA61K49/04
dc.subject.cpcA61K49/106
dc.subject.cpcA61K51/1093
dc.subject.cpcA61L2/0011
dc.subject.cpcC07D487/22
dc.subject.cpcC07H17/02
dc.subject.cpcC07H21/00
dc.subject.uspc540/474
dc.subject.uspc540/145
dc.subject.uspc540/472
dc.titleReduced sp.sup.3 texaphyrins
dc.typePatent
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