Inhibition of histone deacetylase as a treatment for cardiac hypertrophy

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Date

2005-09-20

Authors

Olson, Eric N.
Bristow, Michael R.
McKinsey, Timothy A.
Long, Carlin

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United States Patent and Trademark Office

Abstract

The present invention provides for methods of treating and preventing cardiac hypertrophy. Class II HDACs, which are known to participate in regulation of chromatin structure and gene expression, have been shown to have beneficial effects on cardiac hypertrophy. Surprisingly, the present invention demonstrates that HDAC inhibitors inhibit cardiac hypertrophy by inhibiting fetal cardiac gene expression and interfering with sarcomeric organization.

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