Aptamers for in vivo applications

dc.contributor.advisorEllington, Andrew D.en
dc.creatorYan, Amy Chee, 1973-en
dc.date.accessioned2012-09-10T17:50:57Zen
dc.date.available2012-09-10T17:50:57Zen
dc.date.issued2008-05en
dc.descriptiontexten
dc.description.abstractWhen aptamers emerged almost two decades ago, “selection-ologists” quickly realized the aptamer’s clinical potential - both as a diagnostic tool and as a therapeutic. Since that time, nearly hundreds of medically relevant targets have been successfully selected against. Moreover, many have proven efficacy in tissue culture and animal models. However, only one has successfully advanced to clinical use. Several key limitations in aptamer-based drugs may explain the dearth of aptamers in the pharmacy. Issues of expression level, delivery, and targeting will need to be addressed before aptamers can reach their full clinical potential. This work broaches on aspects of these limitations and leads into ways of transitioning the aptamer into clinical use.en
dc.description.departmentCellular and Molecular Biologyen
dc.format.mediumelectronicen
dc.identifier.urihttp://hdl.handle.net/2152/17832en
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subject.lcshOligonucleotidesen
dc.subject.lcshPharmacologyen
dc.titleAptamers for in vivo applicationsen
thesis.degree.departmentCellular and Molecular Biologyen
thesis.degree.disciplineMolecular Biologyen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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