Therapy of cancer by insect cells containing recombinant baculovirus encoding genes

Date
2002-01-29
Authors
Fidler, Isaiah J.
Dhong, Zhongyun
Lu, Weixin
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Publisher
United States Patent and Trademark Office
Abstract

Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting with various forms of cancer.

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