How complete are current yeast and human protein-interaction networks?

Hart, G. Traver
Ramani, Arun K.
Marcotte, Edward M.
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Genome Biology

We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.

1 Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA -- 2 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Hart, G. Traver, Arun K. Ramani, and Edward M. Marcotte. “How Complete Are Current Yeast and Human Protein-Interaction Networks?” Genome Biology 7, no. 11 (December 1, 2006): 120. doi:10.1186/gb-2006-7-11-120.