Hydrogels for delivery of therapeutic compounds

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Date

2018-04-10

Authors

Laura E. Strong
Nicholas A. Peppas
Jennifer M. Knipe

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United States Patent and Trademark Office

Abstract

In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.

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