Synthetic lipid biology for combinatorial engineering of endotoxin

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Date

2015-02-03

Authors

David P. Giles
M. Stephen Trent
Brittany Needham
Marvin Whiteley

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United States Patent and Trademark Office

Abstract

The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provides for a lipopolysaccharide purified from an engineered strain of E. coli according to Table 1.

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