Erythropoietin response to intermittent hypoxia in health and type 2 diabetes

dc.contributor.advisorLalande, Sophie
dc.contributor.committeeMemberTanaka, Hirofumi
dc.contributor.committeeMemberCoyle, Edward
dc.contributor.committeeMemberBurtscher, Martin
dc.creatorWojan, Frank
dc.creator.orcid0000-0001-8652-1023
dc.date.accessioned2023-07-31T22:17:13Z
dc.date.available2023-07-31T22:17:13Z
dc.date.created2023-05
dc.date.issued2023-04-24
dc.date.submittedMay 2023
dc.date.updated2023-07-31T22:17:14Z
dc.description.abstractPatients with type 2 diabetes and aging individuals experience declines in maximal oxygen consumption. Hemoglobin mass, a component of oxygen transport, strongly correlates to maximal oxygen consumption. Interventions that increase hemoglobin mass may therefore increase maximal oxygen consumption in older adults and patients with type 2 diabetes. Intermittent hypoxia, characterized by alternating periods of breathing low levels of oxygen interspersed with periods breathing normoxic air, has the potential to elicit an acute increase in erythropoietin levels and hemoglobin mass. Despite several instances of repeated exposures to intermittent hypoxia increasing red blood cell count over the course of five days to three weeks, there exists a lack of consistent stimuli across the literature, with deviations in hypoxic duration, number of cycles, and hypoxic severity. Furthermore, studies that successfully increased oxygen transport following intermittent hypoxia did not measure erythropoietin levels, the hormone regulating red cell production, thereby eliminating the possibility for protocol comparison. Therefore, the following three studies aimed to identify the shortest intermittent hypoxia protocol to increase erythropoietin levels in healthy young individuals, and to apply this intermittent hypoxia protocol to older individuals and patients with type 2 diabetes, with the goal of potentially increasing hemoglobin mass. In the first study, we identified the shortest hypoxic protocol within the literature to increase EPO concentrations among young healthy adults. The EPO response to the 32 total hypoxic minutes was no different than a 2-hour continuous hypoxia protocol. In the second study, we demonstrated that EPO concentrations increased following the same intermittent hypoxia in middle-aged adults but found no increase to hemoglobin mass. In the third study, we demonstrated a lack of EPO response to intermittent hypoxia in patients with type 2 diabetes. Furthermore, this study was the first to report hemoglobin mass levels in patients with type 2 diabetes. Collectively, the overall findings highlight the acute effects of intermittent hypoxia on erythropoietin in health and type 2 diabetes.
dc.description.departmentKinesiology and Health Education
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/120711
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/47546
dc.language.isoen
dc.subjectT2D
dc.subjectErythropoietin
dc.subjectIntermittent hypoxia
dc.subjectHemoglobin mass
dc.subjectAging
dc.subjectHypoxia
dc.subjectEPO
dc.subjectType 2 diabetes
dc.titleErythropoietin response to intermittent hypoxia in health and type 2 diabetes
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentKinesiology and Health Education
thesis.degree.disciplineKinesiology
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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