Texaphyrin compounds having improved functionalization

dc.contributor.assigneePharmacyclics, Inc.
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorJonathan L. Sessler
dc.creatorGregory W. Hemmi
dc.creatorTarak D. Mody
dc.date.accessioned2019-10-23T14:31:36Z
dc.date.available2019-10-23T14:31:36Z
dc.date.filed1995-06-02
dc.date.issued1997-02-04
dc.description.abstractTexaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic .pi. system of the macrocycle which stabilizes the metal complex to demetallation and the imine bonds to hydrolysis. The addition of substituents to the 12 and 21 positions of the macrocycle offer steric protection for the imine bonds against possible in vivo enzyme hydrolysis. Electron-withdrawing groups at positions 15 and/or 18 render the macrocycle more readily reduced, i.e. the redox potential is lower and the macrocycle more readily gains an electron to form a radical. Such texaphyrins having a low redox potential and imine bond stabilization are useful in a variety of applications.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber8459333
dc.identifier.patentnumber5599928
dc.identifier.urihttps://hdl.handle.net/2152/76640
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3729
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K41/0009
dc.subject.cpcA61K41/0038
dc.subject.cpcA61K41/0076
dc.subject.cpcA61K49/0021
dc.subject.cpcA61K49/106
dc.subject.cpcA61K51/04
dc.subject.cpcA61K51/0485
dc.subject.cpcA61K51/1093
dc.subject.cpcA61L2/0011
dc.subject.cpcA61K2121/00
dc.subject.cpcC07D487/22
dc.subject.cpcC07H21/00
dc.subject.uspc530/391.1
dc.subject.uspc534/11
dc.subject.uspc540/474
dc.subject.uspc540/145
dc.subject.uspc540/472
dc.titleTexaphyrin compounds having improved functionalization
dc.typePatent
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