Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells

dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.contributor.assigneeGenentech, Inc.
dc.creatorJames Swartz
dc.creatorGeorge M. Georgiou
dc.creatorJi Oiu
dc.creatorPaul H. Bessette
dc.date.accessioned2019-10-23T21:40:34Z
dc.date.available2019-10-23T21:40:34Z
dc.date.filed1997-06-09
dc.date.issued2000-07-04
dc.description.abstractDisclosed are methods and compositions for producing heterologous disulfide bond containing polypeptides in bacterial cells. In preferred embodiments the methods involve co-expression of a prokaryotic disulfide isomerase, such as DsbC or DsbG and a gene encoding a recombinant eukaryotic polypeptide. Exemplary polypeptides disclosed include tissue plasminogen activator.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber8871483
dc.identifier.patentnumber6083715
dc.identifier.urihttps://hdl.handle.net/2152/77238
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/4327
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcC07K14/4743
dc.subject.cpcC07K14/8117
dc.subject.cpcC12N9/0051
dc.subject.cpcC12N9/6459
dc.subject.cpcC12N15/70
dc.subject.cpcC12Y304/21069
dc.subject.uspc435/69.1
dc.subject.uspc435/69.7
dc.subject.uspc435/252.1
dc.subject.uspc435/252.8
dc.subject.uspc435/320.1
dc.subject.uspc536/23.1
dc.subject.uspc536/23.4
dc.titleMethods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
dc.typePatent

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