Superior longitudinal fasciculus microstructure and its functional triple-network mechanisms in depressive rumination

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dc.contributor.advisorSchnyer, David M.
dc.contributor.committeeMemberBeevers, Christopher
dc.creatorPisner, Derek Alexander
dc.date.accessioned2019-04-15T20:09:03Z
dc.date.available2019-04-15T20:09:03Z
dc.date.created2018-12
dc.date.issued2018-12
dc.date.submittedDecember 2018
dc.date.updated2019-04-15T20:09:04Z
dc.description.abstractDepressive rumination, which involves a repetitive focus on one's distress, is associated with function connectivity disturbances of Default-Mode, Salience, and Executive-Control networks, comprising the so-called "triple-network" of attention. Missing, however, is a multimodal account of rumination that neuroanatomically explains the perseveration of these dysfunctional networks as a stable human trait. Using diffusion and functional Magnetic Resonance Imaging, we explored multimodal relationships between rumination severity, white-matter microstructure, and resting-state functional connectivity in N=39 depressed adults, and then directly replicated our findings in a demographically-matched, independent sample (N=39). Among the fully-replicated results, three core findings emerged. First, rumination severity is associated with both disintegrated and desegregated functional connectivity of the triple-network. Second, global microstructural inefficiency of the right Superior Longitudinal Fasciculus (SLF) provides a neuroanatomical connectivity basis for rumination and accounts for anywhere between 25-37% of the variance in rumination (Discovery: p corr<0.01; Replication: p corr<0.01; MSE=0.05). Finally, microstructure of the right SLF and auxiliary white-matter is strongly associated with functional connectivity biomarkers of rumination, both within and between components of the triple-network (Discovery: R²=0.36, p corr<0.05; Replication: R²=0.25, p corr<0.05; MSE=0.04-0.06). By cross-validating discovery with replication, our findings advance a reproducible microstructural-functional brain connectivity model of depressive rumination that unifies neurodevelopmental and neurocognitive perspectives.
dc.description.departmentPsychology
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/74293
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1415
dc.language.isoen
dc.subjectMultimodal
dc.subjectMicrostructure
dc.subjectResting-state
dc.subjectTriple-network
dc.subjectDepressive rumination
dc.subjectReproducibility
dc.titleSuperior longitudinal fasciculus microstructure and its functional triple-network mechanisms in depressive rumination
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentPsychology
thesis.degree.disciplinePsychology
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts

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