Design and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin

dc.contributor.utaustinauthorGuzman-Villanueva, Dianaen_US
dc.contributor.utaustinauthorSmyth, Hugh D. C.en_US
dc.creatorGuzman-Villanueva, Dianaen_US
dc.creatorEl-Sherbiny, Ibrahim M.en_US
dc.creatorHerrera-Ruiz, Deaen_US
dc.creatorSmyth, Hugh D. C.en_US
dc.date.accessioned2016-10-28T19:50:21Z
dc.date.available2016-10-28T19:50:21Z
dc.date.issued2013en_US
dc.description.abstractCurcumin, a yellow polyphenol derived from the turmeric Curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. However, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. In this study, curcumin was encapsulated in a series of novel nano-microparticulate systems developed to improve its aqueous solubility and stability. The nano-microparticulate systems are based entirely on biocompatible, biodegradable, and edible polymers including chitosan, alginate, and carrageenan. The particles were synthesized via ionotropic gelation. Encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution compared to the free form of curcumin. Also, the in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems after 9 hours in PBS at pH 7.4 when freeze-dried particles were used.en_US
dc.description.departmentPharmaceutical Sciencesen_US
dc.description.sponsorshipCONACYTen_US
dc.description.sponsorshipCUPIAen_US
dc.identifierdoi:10.15781/T26T0GZ8D
dc.identifier.citationGuzman-Villanueva, Diana, Ibrahim M. El-Sherbiny, Dea Herrera-Ruiz, and Hugh DC Smyth. "Design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin." BioMed research international 2013 (2013).en_US
dc.identifier.doi10.1155/2013/724763en_US
dc.identifier.issn2314-6133en_US
dc.identifier.urihttp://hdl.handle.net/2152/43190
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.relation.ispartofserialBiomed Research Internationalen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.rights.restrictionOpenen_US
dc.subjectcontrolled drug-deliveryen_US
dc.subjectchemopreventive agenten_US
dc.subjectprostate-canceren_US
dc.subjectprotein drugsen_US
dc.subjectoral deliveryen_US
dc.subjectppar-gammaen_US
dc.subjectalginateen_US
dc.subjectchitosanen_US
dc.subjectbioavailabilityen_US
dc.subjectnanoparticlesen_US
dc.subjectbiotechnology & applied microbiologyen_US
dc.subjectmedicine, research & experimentalen_US
dc.titleDesign and in Vitro Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcuminen_US
dc.typeArticleen_US

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