To achieve the optimum functionality and mechanical properties in the AM-based parts, it is vital to fully characterize parts under static mechanical loadings (tension, compression, and flexure) that are built in different orientations. This research reports the results of the compression (ASTM standard D695), 4-point flexure (ASTM D790), and tensile (ASTM D 638 Type I) tests on the ABS plastic specimens that are designed according to the ASTM standards and are built in different orientations using the uPrint SE Plus 3D printer. This study examined the effects that printing 3D parts in different orientations (build angles) has on the mechanical properties of ABS P430 plastic. A total of 45 samples (15 tension, 15 compression, and 15 flexure) were printed in 5 orientations; 0 degrees in the XY plane, 45 degrees in the XY plane, 90 degrees in the XY plane, 45 degrees in the Z plane, and 90 degrees in the Z plane. The hypothesis was that the samples printed 0 degrees in the XY plane would be the strongest in compression and flexure, and also have the greatest modulus of elasticity. The samples printed 90 degrees in the XY plane were predicted to be the strongest in tension, having the largest tensile strength and lowest modulus of elasticity. The findings showed that printing 90 degrees in the XY plane resulted in the highest tensile strength compared to the other orientations, but not by a significant margin. Printing 0 degrees in the XY plane significantly increased the compressive and flexure strengths of the material compared to other orientations.