HDL particles for delivery of nucleic acids

dc.contributor.assigneeUniversity of North Texas Health Science Center at Fort Worth
dc.contributor.assigneeBoard of Regents, Univ. of Tex. Sys.
dc.creatorLopez-Berestein, Gabriel
dc.creatorProkai, Laszlo
dc.creatorSood, Anil K.
dc.creatorLacko, Andras G.
dc.creatorMangala, Lingegowda S.
dc.creatorMcConathy, Walter J.
dc.creatorNair, Maya P.
dc.date.accessioned2019-05-14T14:32:55Z
dc.date.available2019-05-14T14:32:55Z
dc.date.filed2014-05-27
dc.date.issued2014-05-27
dc.description.abstractDisclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein; (b) a nucleic acid component comprising a therapeutic nucleic acid segment; and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber13129349
dc.identifier.patentnumber8734853
dc.identifier.urihttps://hdl.handle.net/2152/74565
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1683
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.subject.cpcA61K47/6911
dc.subject.cpcA61K48/0041
dc.subject.cpcC07K14/775
dc.subject.cpcC12N15/111
dc.subject.cpcC12N15/88
dc.subject.cpcC12N2320/32
dc.subject.uspc424/499
dc.subject.uspc514/44A
dc.subject.uspc514/44R
dc.titleHDL particles for delivery of nucleic acids
dc.typePatent
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