Blood shear stress and flow velocity : challenges for laser coagulation and hemostasis of large vessels

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dc.contributor.advisorMilner, Thomas E.
dc.creatorKatta, Nitesh
dc.creator.orcid0000-0001-8097-5489
dc.date.accessioned2022-09-17T22:26:14Z
dc.date.available2022-09-17T22:26:14Z
dc.date.created2019-05
dc.date.issued2019-06-20
dc.date.submittedMay 2019
dc.date.updated2022-09-17T22:26:15Z
dc.description.abstractPhoto-coagulation of blood vessels offers stark advantages to current radiofrequency mediated devices, given the high specificity of blood absorption wavelengths (like 532nm, 1.064 μm). Existing literature has documented coagulation in treatment of pediatric vascular diseases like port-wine stains for microvascular hemostasis. Although laser treatments have been successful in smaller diameter blood vessels, treatment of larger sized vessels are less effective in achieving hemostasis. This report investigates the hypothesis that a primary limitation in coagulation of larger sized vessels comes from shear stress gradients with higher flow velocities along with temperature dependent viscosity changes. Laser coagulation at the 1.07 μm wavelength is tested in the chicken chorio-allantoic membrane (CAM) model highlighting limitations reported in the archival literature. COMSOL based finite element models are presented which includes hypothetical limitations in coagulation during laser irradiation. Laser fluence rate and dosimetry are adjusted based on experimental OCT imaging and angiography observations as well as COMSOL models to test the hypothesis that blood shear stress and flow velocity are important challenges for laser coagulation and hemostasis of large vessels
dc.description.departmentElectrical and Computer Engineering
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/115783
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/42681
dc.language.isoen
dc.subjectHemostasis
dc.subjectLaser
dc.subjectPhotothermolysis
dc.subjectCoagulation
dc.subjectCAMs
dc.subjectChorio-allantoic membrane
dc.subjectLaser coagulation
dc.subjectBlood vessel coagulation
dc.subjectPhoto-coagulation
dc.subjectOCT
dc.subjectOptical coherence tomography
dc.titleBlood shear stress and flow velocity : challenges for laser coagulation and hemostasis of large vessels
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentElectrical and Computer Engineering
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Engineering

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