Method of identifying inhibitors of glutathione S-transferase (GST) gene expression

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Date

1999-10-19

Authors

Lopez-Berestein, Gabriel
Buolamwini, John K.
Keller, Charles W.
Ali-Osman, Francis
Antoun, Gamil
Lo, Hui-Wen
Akande, Olanike

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United States Patent and Trademark Office

Abstract

Complementary DNA and genomic clones for three variants of GST-.pi. are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer. This permits the detection and treatment of certain classes of tumors using new compositions such as GST-.pi. genes, oligonucleotides, peptides and antibodies.

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