A closed-loop multi-scale model of the cardiovascular system for evaluation of ventricular assist devices

dc.contributor.advisorMoser, Robert deLancey
dc.creatorGohean, Jeffrey Robert
dc.date.accessioned2017-02-10T15:01:24Z
dc.date.available2017-02-10T15:01:24Z
dc.date.issued2007-05
dc.description.abstractCardiovascular disease is the number one killer in America as well as most Westernized countries and is the primary cause of congestive heart failure. Over five million Americans are currently living with heart failure and over half a million more are diagnosed each year. Mechanical assist devices are used as a bridge to transplant and as destination therapy in people with severe heart failure. While these devices are highly engineered, their optimal implant configuration and settings have yet to be determined. A computational model has been developed in order to study the effect of these assist devices on the cardiovascular system. The model is multi-dimensional, making use of a quasi-one-dimensional arterial tree model for the systemic arteries coupled with lumped parameter models for the venous return and pulmonary circulation. In addition, a dynamic aortic valve model has been developed to account for the brief period of backflow at the onset of diastole and a complex impedance representation of the small arteries has been used as the outflow boundary condition to the arterial tree to account for phase-lag and wave reflection. The model produces physiologically consistent pressure and flow curves for both healthy and disease states, and preliminary validation has been performed against clinical data from patients under various levels of mechanical assist.en_US
dc.description.departmentMechanical Engineeringen_US
dc.format.mediumelectronicen_US
dc.identifierdoi:10.15781/T2HD7NX9T
dc.identifier.urihttp://hdl.handle.net/2152/45625
dc.language.isoengen_US
dc.relation.ispartofUT Electronic Theses and Dissertationsen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.rights.restrictionRestricteden_US
dc.subjectCardiovascular diseaseen_US
dc.subjectMechanical assist devicesen_US
dc.subjectArtificial hearten_US
dc.titleA closed-loop multi-scale model of the cardiovascular system for evaluation of ventricular assist devicesen_US
dc.typeThesisen_US
dc.type.genreThesisen_US
thesis.degree.departmentMechanical Engineeringen_US
thesis.degree.disciplineMechanical Engineeringen_US
thesis.degree.grantorUniversity of Texas at Austinen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US

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