Investigation of G-Quadruplex DNA cleavage through development of a solution-based fluorescent assay

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2012-12

Authors

Schoonover, Michelle Lea

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Abstract

In vitro, G-rich sequences form highly stable secondary structures known as G-Quadruplexes. These structures have been characterized by circular dichroism nuclear magnetic resonance and X-ray crystallography; although their detection in vivo has remained elusive. Due to the biological implication of a transisent and polymorphic secondary structure forming within the hypothetical G-Quadruplex forming regions, there is growing interest to understand their in vivo molecular dynamics.

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