Circadian and Social Cues Regulate Ion Channel Trafficking

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Date

2009-09-29

Authors

Markham, Michael R.
McAnelly, M. Lynne
Stoddard, Philip K.
Zakon, Harold

Journal Title

Journal ISSN

Volume Title

Publisher

Public Library of Science

Abstract

Electric fish generate and sense electric fields for navigation and communication. These signals can be energetically costly to produce and can attract electroreceptive predators. To minimize costs, some nocturnally active electric fish rapidly boost the power of their signals only at times of high social activity, either as night approaches or in response to social encounters. Here we show that the gymnotiform electric fish Sternopygus macrurus rapidly boosts signal amplitude by 40% at night and during social encounters. S. macrurus increases signal magnitude through the rapid and selective trafficking of voltage-gated sodium channels into the excitable membranes of its electrogenic cells, a process under the control of pituitary peptide hormones and intracellular second-messenger pathways. S. macrurus thus maintains a circadian rhythm in signal amplitude and adapts within minutes to environmental events by increasing signal amplitude through the rapid trafficking of ion channels, a process that directly modifies an ongoing behavior in real time.

Description

Michael R. Markham is with UT Austin and Florida International University, M. Lynne McAnelly is with UT Austin, Philip K. Stoddard is with Florida International University, Harold H. Zakon is with UT Austin.

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Citation

Markham MR, McAnelly ML, Stoddard PK, Zakon HH (2009) Circadian and Social Cues Regulate Ion Channel Trafficking. PLoS Biol 7(9): e1000203. doi:10.1371/journal.pbio.1000203