Water Content and Thermoplastic Polyurethane Effects on Thrombosis Clotting

Date

2019-04

Authors

Small, Madeline
Jackson, Monica
Neuenschwander, Pierre
Chou, Shih-Feng

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Engineering Education

Abstract

One of the main factors that can increase the chance of heart disease is unwanted blood clotting, or thrombosis. In addition, implantable biomaterials and/or medical devices are likely to trigger a series of adverse reactions that can lead to unwanted blood clotting. Herein, we study a thromboresistant polymeric material, specifically thermoplastic polyurethanes (TPUs), on their physical properties and anticoagulation performance. Their hydrophobic nature and superior mechanical properties make them an ideal candidate for coating materials on implantable medical devices, such as vascular stents. Our results show that hydrophobic TPUs absorbed minimal to negligible water content and provided excellent thromboresistant properties against human plasma.

Description

LCSH Subject Headings

Citation

Small, M., & Jackson, M., & Neuenschwander, P., & Chou, S. (2019, April), Water Content and Thermoplastic Polyurethane Effects on Thrombosis Clotting Paper presented at 2018 ASEE Gulf-Southwest Section Annual Meeting, AT&T Executive Education and Conference Center, Austin, TX 78705. https://peer.asee.org/31610