Efficacy Of Posaconazole As Treatment And Prophylaxis Against Fusarium Solani

dc.contributor.utaustinauthorWiederhold, Nathan P.en
dc.creatorWiederhold, Nathan P.en
dc.creatorNajvar, Laura K.en
dc.creatorBocanegra, Rosieen
dc.creatorGraybill, John R.en
dc.creatorPatterson, Thomas F.en
dc.date.accessioned2015-09-09T15:51:37Zen
dc.date.available2015-09-09T15:51:37Zen
dc.date.issued2010-03en
dc.description.abstractInvasive fusariosis is a highly aggressive fungal infection associated with high mortality in heavily immunocompromised patients. Although posaconazole is efficacious as salvage therapy against infections caused by Fusarium species, concerns remain regarding this agent in the setting of reduced potency. To evaluate the efficacy of posaconazole as treatment or prophylaxis against invasive fusariosis caused by Fusarium solani, we utilized a neutropenic murine model of disseminated disease. ICR mice were administered escalating doses of posaconazole (6.25, 12.5, 25, or 50 mg/kg of body weight twice daily [BID]) by oral gavage beginning 2 days prior to inoculation in the prophylaxis studies or beginning 12 h after inoculation as treatment. Therapy was continued until day 9 postinoculation, and animals were monitored off therapy until day 15 for survival. Fungal burden was assessed as CFU in the kidneys. A clear dose-response relationship was observed, as the highest dose of posaconazole (50 mg/kg) was the most effective in prolonging survival and reducing tissue fungal burden both as prophylaxis and as treatment. This dose response was associated with high posaconazole serum concentrations as measured by bioassay. However, the extent of efficacy was also dependent on the infecting inoculum, as greater increases in survival and reductions in fungal burden were observed with the lower inocula tested. In this model high dosages of posaconazole were effective as treatment and prophylaxis against disseminated fusariosis caused by F. solani.en
dc.description.departmentPharmaceutical Sciencesen
dc.description.sponsorshipen
dc.identifier.citationWiederhold, N. P., Najvar, L. K., Bocanegra, R., Graybill, J. R., & Patterson, T. F. (Mar., 2010). Efficacy of Posaconazole as Treatment and Prophylaxis against Fusarium solani. Antimicrobial Agents and Chemotherapy, 54(3), 1055–1059. doi:10.1128/AAC.01445-09en
dc.identifier.doi10.1128/aac.01445-09en
dc.identifier.issn0066-4804en
dc.identifier.urihttp://hdl.handle.net/2152/31233en
dc.identifier.urlen
dc.language.isoEnglishen
dc.relation.ispartofserialAntimicrobial Agents and Chemotherapyen
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.rights.holderen
dc.subjectcell transplant recipientsen
dc.subjectin-vitro activitiesen
dc.subjectoral posaconazoleen
dc.subjectinvasive aspergillosisen
dc.subjecthematologic malignancyen
dc.subjectamphotericin-ben
dc.subjectpharmacokineticsen
dc.subjectvoriconazoleen
dc.subjecttriazolesen
dc.subjectinfectionen
dc.subjectmicrobiologyen
dc.subjectpharmacology & pharmacyen
dc.titleEfficacy Of Posaconazole As Treatment And Prophylaxis Against Fusarium Solanien
dc.typeArticleen

Access full-text files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
EfficacyOfPosaconazole.pdf
Size:
511.06 KB
Format:
Adobe Portable Document Format