Assessment Of Serum (1 -> 3)-Beta-D-Glucan Concentration As A Measure Of Disease Burden In A Murine Model Of Invasive Pulmonary Aspergillosis

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Date

2008-03

Authors

Wiederhold, Nathan P.
Najvar, Laura K.
Vallor, Ana C.
Kirkpatrick, William R.
Bocanegra, Rosie
Molina, Destiny
Olivo, Marcos
Graybill, John R.
Patterson, Thomas F.

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Abstract

Serum (1 -> 3)-beta-D-glucan concentrations were serially measured in the presence and absence of antifungal therapy in a murine model of invasive pulmonary aspergillosis. Serum (1 -> 3)-beta-D-glucan was detected early during the course of infection, and reductions in this biomarker were associated with improved survival in animals treated with antifungal agents.

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Nathan P. Wiederhold, Laura K. Najvar, Ana C. Vallor, William R. Kirkpatrick, Rosie Bocanegra, Destiny Molina, Marcos Olivo, John R. Graybill, Thomas F. Patterson. Assessment Of Serum (1 -> 3)-Beta-D-Glucan Concentration As A Measure Of Disease Burden In A Murine Model Of Invasive Pulmonary Aspergillosis. Antimicrobial Agents Chemotherapy, (Mar., 2008) Vol. 52 No. 3 1176-1178. DOI: 10.1128/aac.01425-07