pH dependent polymer micelles

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Date

1999-09-21

Authors

Stephen Webber
Thomas J. Martin

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United States Patent and Trademark Office

Abstract

The present invention relates to the use of poly(vinyl N-heterocycle)-block-poly(alkylene oxide) copolymers in micelle containing pharmaceutical formulations. The copolymers advantageously respond to pH differences in the environment to which they are exposed forming micelles at higher pH values. The micelles, which comprise a therapeutic compound and a copolymer, deliver drug in a pH dependent manner.

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