Influenza A virus vaccines and inhibitors

dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorEdward C. Arnold
dc.creatorRobert M. Krug
dc.creatorKaren Y. Twu
dc.creatorGaetano T. Montelione
dc.creatorKalyan Kumar Das
dc.creatorLi-Chung Ma
dc.creatorRong Xiao
dc.creatorRei-Lin Kuo
dc.date.accessioned2019-10-23T19:31:04Z
dc.date.available2019-10-23T19:31:04Z
dc.date.filed2006-12-02
dc.date.issued2010-05-04
dc.description.abstractThe present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber11566216
dc.identifier.patentnumber7709190
dc.identifier.urihttps://hdl.handle.net/2152/77022
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/4111
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61B50/39
dc.subject.cpcA61K38/162
dc.subject.cpcA61K39/145
dc.subject.cpcA61K2039/5254
dc.subject.cpcA61K2039/53
dc.subject.cpcC07K14/005
dc.subject.cpcC07K14/47
dc.subject.cpcC12N7/00
dc.subject.cpcC12N2760/16034
dc.subject.cpcC12N2760/16071
dc.subject.cpcC12N2760/16122
dc.subject.cpcC12N2760/16134
dc.subject.cpcC12N2760/16162
dc.subject.uspc435/5
dc.titleInfluenza A virus vaccines and inhibitors
dc.typePatent

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