Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus

dc.creatorJehee, Janneke F. M.en
dc.creatorBallard, Dana H.en
dc.date.accessioned2013-06-28T15:48:52Zen
dc.date.available2013-06-28T15:48:52Zen
dc.date.issued2009-05-01en
dc.descriptionJanneke F. M. Jehee is with University of Rochester and Vanderbilt University, Dana H. Ballard is with University of Rochester and UT Austin.en
dc.description.abstractBiphasic neural response properties, where the optimal stimulus for driving a neural response changes from one stimulus pattern to the opposite stimulus pattern over short periods of time, have been described in several visual areas, including lateral geniculate nucleus (LGN), primary visual cortex (V1), and middle temporal area (MT). We describe a hierarchical model of predictive coding and simulations that capture these temporal variations in neuronal response properties. We focus on the LGN-V1 circuit and find that after training on natural images the model exhibits the brain's LGN-V1 connectivity structure, in which the structure of V1 receptive fields is linked to the spatial alignment and properties of center-surround cells in the LGN. In addition, the spatio-temporal response profile of LGN model neurons is biphasic in structure, resembling the biphasic response structure of neurons in cat LGN. Moreover, the model displays a specific pattern of influence of feedback, where LGN receptive fields that are aligned over a simple cell receptive field zone of the same polarity decrease their responses while neurons of opposite polarity increase their responses with feedback. This phase-reversed pattern of influence was recently observed in neurophysiology. These results corroborate the idea that predictive feedback is a general coding strategy in the brain.en
dc.description.departmentComputer Sciencesen
dc.description.sponsorshipThis work was supported by National Institutes of Health research grants EY05729 and R01 RR009283 and by a Rubicon grant from the Netherlands Organization for Scientific Research (NWO). The funding agencies did not have any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationJehee JFM, Ballard DH (2009) Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus. PLoS Comput Biol 5(5): e1000373. doi:10.1371/journal.pcbi.1000373en
dc.identifier.doi10.1371/journal.pcbi.1000373en
dc.identifier.urihttp://hdl.handle.net/2152/20550en
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.rightsCC-BYen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.subjectCell polarityen
dc.subjectCoding mechanismsen
dc.subjectCognitionen
dc.subjectDetectorsen
dc.subjectNeuronsen
dc.subjectNeurophysiologyen
dc.subjectVisionen
dc.subjectVisual cortexen
dc.titlePredictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleusen
dc.typeArticleen

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