Variation in the Biomolecular Interactions of Nickel(Ii) Hydrazone Complexes Upon Tuning the Hydrazide Fragment

dc.contributor.utaustinauthorButorac, Rachel R.en_US
dc.contributor.utaustinauthorCowley, Alan H.en_US
dc.creatorKrishnamoorthy, Paramasivamen_US
dc.creatorSathyadevi, Palanissamyen_US
dc.creatorButorac, Rachel R.en_US
dc.creatorCowley, Alan H.en_US
dc.creatorBhuvanesh, Nattamai S. P.en_US
dc.creatorDharmaraj, Nallasamyen_US
dc.date.accessioned2016-09-23T18:05:10Z
dc.date.available2016-09-23T18:05:10Z
dc.date.issued2012-03en_US
dc.description.abstractThree new bivalent nickel hydrazone complexes have been synthesised from the reactions of [NiCl2(PPh3)(2)] with H2L {L = dianion of the hydrazones derived from the condensation of o-hydroxynaphthaldehyde with furoic acid hydrazide (H2L1) (1)/thiophene-2-acid hydrazide (H2L2) (2)/isonicotinic acid hydrazide (H2L3) (3)} and formulated as [Ni(L-1)(PPh3)] (4), [Ni(L-2)(PPh3)] (5) and [Ni(L-3)(PPh3)] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(II) chelates have been screened for their scavenging effect towards O-2(-), OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.en_US
dc.description.departmentChemistryen_US
dc.description.sponsorshipUniversity Grants Commission, New Delhi under the UGC-SAP-DRSen_US
dc.description.sponsorshipRobert A. Welch Foundation F-0003en_US
dc.identifierdoi:10.15781/T2S46H71P
dc.identifier.citationKrishnamoorthy, Paramasivam, Palanisamy Sathyadevi, Rachel R. Butorac, Alan H. Cowley, Nattamai SP Bhuvanesh, and Nallasamy Dharmaraj. "Variation in the biomolecular interactions of nickel (II) hydrazone complexes upon tuning the hydrazide fragment." Dalton Transactions 41, no. 22 (Mar., 2012): 6842-6854.en_US
dc.identifier.doi10.1039/c2dt30121ken_US
dc.identifier.issn1477-9226en_US
dc.identifier.urihttp://hdl.handle.net/2152/41042
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.relation.ispartofserialDalton Transactionsen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.rights.restrictionOpenen_US
dc.subjectbovine serum-albuminen_US
dc.subjectbiological-activityen_US
dc.subjectcrystal-structureen_US
dc.subjectdna-bindingen_US
dc.subjectfluorescence spectroscopyen_US
dc.subjectin-vitroen_US
dc.subjectcopper(ii) complexesen_US
dc.subjectcytotoxic activitiesen_US
dc.subjectprotein-bindingen_US
dc.subjectantioxidanten_US
dc.subjectchemistry, inorganic & nuclearen_US
dc.titleVariation in the Biomolecular Interactions of Nickel(Ii) Hydrazone Complexes Upon Tuning the Hydrazide Fragmenten_US
dc.typeArticleen_US

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