Methods for fine particle manufacture

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorHugh D. Smyth
dc.creatorMatthew Herpin
dc.date.accessioned2019-10-23T14:33:47Z
dc.date.available2019-10-23T14:33:47Z
dc.date.filed2014-08-13
dc.date.issued2016-06-21
dc.description.abstractProcesses for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber14458818
dc.identifier.patentnumber9370514
dc.identifier.urihttps://hdl.handle.net/2152/76736
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3825
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K31/496
dc.subject.cpcA61K9/14
dc.subject.cpcA61K9/145
dc.subject.cpcA61K31/192
dc.subject.cpcA61K2300/00
dc.subject.uspcNo longer published
dc.titleMethods for fine particle manufacture
dc.typePatent

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