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dc.contributor.advisorMilner, Thomas E.en
dc.creatorQiu, Jinzeen
dc.date.accessioned2012-02-14T16:06:41Zen
dc.date.available2012-02-14T16:06:41Zen
dc.date.issued2010-12en
dc.date.submittedDecember 2010en
dc.identifier.urihttp://hdl.handle.net/2152/ETD-UT-2010-12-1644en
dc.descriptiontexten
dc.description.abstractThe main purpose of this research was to investigate new medical applications of femtosecond laser ablation. A near-infrared femtosecond laser was tested and proved to be able to overcome the existing limitations and outperform the conventional long-pulse lasers in the areas of human urinary calculus (kidney stone) lithotripsy and skin treatment. The two primary objectives of my research are: 1) to investigate the feasibility of using femtosecond pulsed laser radiation to ablate urinary calculus of various compositions. The laser-calculus interaction mechanism was characterized using pump probe imaging and fast flash imaging. A novel fiber delivery system was developed to transmit and focus high energy femtosecond pulses for urinary calculus lithotripsy. The successful demonstration of the femtosecond laser lithotripsy provided a promising treatment method better than the existing long-pulse laser lithotripsy in a few different aspects, including less collateral damage to surrounding tissue, small-size debris and more controlled experimental condition. 2) to investigate the depth limitation of femtosecond subsurface ablation in scattering skin sample and develop a prototype tissue optical clearing device to enhance femtosecond beam penetration for deeper subsurface cavitation production in the skin. The successful demonstration of the device has potential benefits to new femtosecond-based therapies for reshaping or removing subcutaneous tissues.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.subjectFemtosecond laseren
dc.subjectLaser lithotripsyen
dc.subjectFluoride fiberen
dc.subjectUrinary calculien
dc.subjectErbium YAG laseren
dc.subjectSapphire fiberen
dc.subjectPlasmaen
dc.titleNew biomedical applications of near-infrared femtosecond laser ablationen
dc.date.updated2012-02-14T16:06:58Zen
dc.identifier.slug2152/ETD-UT-2010-12-1644en
dc.contributor.committeeMemberNeev, Josephen
dc.contributor.committeeMemberTeichman, Joel M.en
dc.contributor.committeeMemberTunnell, Jamesen
dc.contributor.committeeMemberDunn, Andrewen
dc.contributor.committeeMemberDowner, Mikeen
dc.contributor.committeeMemberChan, Kin F.en
dc.description.departmentBiomedical Engineeringen
dc.type.genrethesisen
thesis.degree.departmentBiomedical Engineeringen
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorUniversity of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen


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