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dc.contributor.advisorGross, Jeffrey Martinen
dc.creatorHayes, Julie Marieen
dc.date.accessioned2010-12-17T20:58:50Zen
dc.date.accessioned2010-12-17T20:58:58Zen
dc.date.available2010-12-17T20:58:50Zen
dc.date.available2010-12-17T20:58:58Zen
dc.date.issued2010-08en
dc.date.submittedAugust 2010en
dc.identifier.urihttp://hdl.handle.net/2152/ETD-UT-2010-08-1966en
dc.descriptiontexten
dc.description.abstractFibronectin (fn) and integrin α5 (itgα5) are both key players in cell adhesion and intracellar signaling, however the specific in vivo role of these proteins has never been analyzed in the vertebrate lens. The results presented here indicate that Fn1 and Itgα5 proteins are essential for the proper development of the lens. The loss of Fn1 protein in the zebrafish embryo results in distinct adhesion defects, defects in lens fiber morphogenesis, and cataracts. These results were phenocopied in zebrafish itga5 mutants, thereby indicating an essential role for Fn1 and Itgα5 during lens development. Furthermore, embryos with reduced levels of ptk2.1 (focal adhesion kinase – FAK) also phenocopied the defective fn1 and itgα5 lens, suggesting that FAK is a major player in the intracellular signaling mediated by Fn1/Itgα5 interactions in the lens.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.subjectZebrafishen
dc.subjectLensen
dc.subjectIntegrinen
dc.subjectFibronectionen
dc.subjectFAKen
dc.titleIntegrin alphα5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafishen
dc.date.updated2010-12-17T20:58:58Zen
dc.contributor.committeeMemberWallingford, John B.en
dc.description.departmentInstitute for Cellular and Molecular Biologyen
dc.type.genrethesisen
thesis.degree.departmentCellular and Molecular Biology, Institute foren
thesis.degree.disciplineCell and Molecular Biologyen
thesis.degree.grantorUniversity of Texas at Austinen
thesis.degree.levelMastersen
thesis.degree.nameMaster of Artsen


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