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    Rheological, In Situ Printability and Cell Viability Analysis of Hydrogels for Muscle Tissue Regeneration

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    Date
    2018
    Author
    Ramesh, Srikanthan
    Gerdes, Sam
    Lau, Sharon
    Mostafavi, Azadeh
    Kong, Zhenyu
    Johnson, Blake N.
    Tamayol, Ali
    Rao, Prahalada
    Rivero, Iris V.
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    Abstract
    Advancements in additive manufacturing have made it possible to fabricate biologically relevant architectures from a wide variety of materials. Hydrogels have garnered increased attention for the fabrication of muscle tissue engineering constructs due to their resemblance to living tissue and ability to function as cell carriers. However, there is a lack of systematic approaches to screen bioinks based on their inherent properties, such as rheology, printability and cell viability. Furthermore, this study takes the critical first-step for connecting in-process sensor data with construct quality by studying the influence of printing parameters. Alginate-chitosan hydrogels were synthesized and subjected to a systematic rheological analysis. In situ print layer photography was utilized to identify the optimum printing parameters and also characterize the fabricated three-dimensional structures. Additionally, the scaffolds were seeded with C2C12 mouse myoblasts to test the suitability of the scaffolds for muscle tissue engineering. The results from the rheological analysis and print layer photography led to the development of a set of optimum processing conditions that produced a quality deposit while the cell viability tests indicated the suitability of the hydrogel for muscle tissue engineering applications.
    Department
    Mechanical Engineering
    Subject
    printability
    muscle regeneration
    in-situ monitoring
    bioprinting
    C2C12 myoblasts
    URI
    https://hdl.handle.net/2152/90160
    http://dx.doi.org/10.26153/tsw/17081
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    University of Texas at Austin Libraries
    • facebook
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    © The University of Texas at Austin