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dc.contributor.advisorWhitman, Christian P.
dc.creatorJewett, Ashley Lauren
dc.date.accessioned2019-12-02T22:47:52Z
dc.date.available2019-12-02T22:47:52Z
dc.date.created2019-05
dc.date.issued2019-05-10
dc.date.submittedMay 2019
dc.identifier.urihttps://hdl.handle.net/2152/78621
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/5677
dc.description.abstractStudy of the aza-Bergman rearrangement was expanded to include thermolysis of the 1,2-dialkynylpyrrole (1,2-DAP) and a 1,5-dialkynylpyrazole (1,5-DAPz). The product obtained from thermolysis of 1,2-DAP was a six-membered pyridine-containing species, resulting from the rearrangement of the starting 1,2-DAP to a cumulene intermediate and then finally to a carbene-containing species. After performing kinetics experiments of the thermolysis with the 1,2-DAP, the resulting experimental calculations were found to be within good agreement of theoretical calculations for the aza-Bergman rearrangement. Thermolysis of a 1,5-DAPz, however, resulted in a variety of different products. The mechanism of formation behind these products have not been confirmed, but several possibilities are put forth.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectBergman cyclization
dc.subjectBergman rearrangement
dc.subjectaza-Bergman
dc.subjectDialkynylpyrrole
dc.titleCarbene and diradical-generating cyclizations of dialkynyl azoles
dc.typeThesis
dc.date.updated2019-12-02T22:47:53Z
dc.contributor.committeeMemberFast, Walter
dc.description.departmentPharmaceutical Sciences
thesis.degree.departmentPharmaceutical Sciences
thesis.degree.disciplinePharmaceutical Sciences
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Pharmaceutical Sciences
dc.type.materialtext


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