Antagonists of LHRH
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Date
1997-08-12
Authors
Karl A. Folkers
Cyril Y. Bowers
Anna Janecka
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
LHRH analogs and congeners with high water solubility have been synthesized. These new analogs had 0%-100% antiovulatory activity at a 0.5 .mu.g dosage and 0%-80% at 0.25 .mu.g. The ED.sub.50 for histamine release was 30.5 .mu.g/ml->300 .mu.g/ml.