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dc.creatorJonathan L. Sessler
dc.creatorGregory W. Hemmi
dc.creatorTarak D. Mody
dc.creatorVladimir A. Kral
dc.date.accessioned2019-10-23T21:40:19Z
dc.date.available2019-10-23T21:40:19Z
dc.date.issued1998-09-01
dc.identifier.urihttps://hdl.handle.net/2152/77206
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/4295
dc.description.abstractTexaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.titleMetal complexes of texaphyrins
dc.typePatent
dc.description.departmentBoard of Regents, University of Texas System
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.date.filed1996-09-13
dc.subject.cpcA61K51/0485
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dc.identifier.patentnumber5801229
dc.identifier.applicationnumber8713701
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