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    Metal complexes of texaphyrins

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    US5801229.pdf (2.898Mb)
    Date
    1998-09-01
    Author
    Jonathan L. Sessler
    Gregory W. Hemmi
    Tarak D. Mody
    Vladimir A. Kral
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    Abstract
    Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
    Department
    Board of Regents, University of Texas System
    URI
    https://hdl.handle.net/2152/77206
    http://dx.doi.org/10.26153/tsw/4295
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