Show simple item record

dc.creatorJonathan L. Sessler
dc.creatorDarren Magda
dc.date.accessioned2019-10-23T21:40:11Z
dc.date.available2019-10-23T21:40:11Z
dc.date.issued1998-02-03
dc.identifier.urihttps://hdl.handle.net/2152/77190
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/4279
dc.description.abstractMethods for photocleavage of a polymer of ribonucleic acid using a texaphyrin or a texaphyrin metal complex are provided. A preferred method of use is the site-specific cleavage of a polymer of ribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide. Possible substrates for cleavage include messenger, ribosomal, transfer, small nuclear, and small cytosolic ribonucleic acids, and RNA cofactors, thereby inactivating these ribonucleic acids and providing a multifaceted approach for treating benign or malignant cancer cells, or other undesired cells or tissues.
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.titleRNA photocleavage using texaphyrins
dc.typePatent
dc.description.departmentBoard of Regents, University of Texas System
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.contributor.assigneePharmacyclics, Inc.
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.date.filed1995-06-07
dc.subject.cpcA61K41/0042
dc.subject.cpcA61K51/0497
dc.identifier.patentnumber5714328
dc.identifier.applicationnumber8484551
dc.subject.uspc424/9.362
dc.subject.uspc435/6.16
dc.subject.uspc435/5
dc.subject.uspc514/15.1
dc.subject.uspc514/19.3
dc.subject.uspc514/44R
dc.subject.uspc536/24.5


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record