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dc.creatorPaul S. Ho
dc.creatorZhi-Quan Luo
dc.creatorSalomon Stavchansky
dc.creatorZhuojie Wu
dc.creatorAshish Rastogi
dc.creatorPhillip L. Bowman
dc.date.accessioned2019-10-23T14:33:14Z
dc.date.available2019-10-23T14:33:14Z
dc.date.issued2015-04-14
dc.identifier.urihttps://hdl.handle.net/2152/76660
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3749
dc.description.abstractA method of making an injectable or implantable active agent delivery device capable of delivering a diagnostic, therapeutic, and/or prophylactic agent to a desired targeted site having orifice(s) on the surface is disclosed herein providing unidirectional release of the agent at a controlled desirable rate. The agent may include, but is not limited to, drugs, proteins, peptides, biomarkers, bioanalytes, and/or genetic material. The technology of the invention is based on parallel processing to fabricate micro-holes on tubes employing photo-lithography and reactive ion etching techniques and also incorporates a simple molding method to form the micro-holes on flexible polymer tubes, including bio-degradable tubes. The parallel processing method of the instant invention is fast, economical and well suited for mass production. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time.
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.titleMethods for making controlled delivery devices having zero order kinetics
dc.typePatent
dc.description.departmentBoard of Regents, University of Texas System
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.date.filed2010-07-14
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dc.identifier.patentnumber9005649
dc.identifier.applicationnumber13383820
dc.subject.uspc424/423


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