Short synthetic route to taxol and taxol derivatives
Access full-text files
Date
1996-04-16
Authors
Philip D. Magnus
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
A short route to the total synthesis of the core skeleton of the taxol ring system is described. The same sequence of transformations can be carried out to make the 7-hydroxy series, and connect the additional carbon atoms required for the A-ring. The number of steps to the taxane skeleton is 13, making it the shortest route from readily available inexpensive starting materials.