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dc.creatorOlson, Eric N.
dc.creatorvan Rooij, Eva
dc.date.accessioned2019-05-14T14:33:02Z
dc.date.available2019-05-14T14:33:02Z
dc.date.issued2015-01-27
dc.identifier.urihttps://hdl.handle.net/2152/74574
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1692
dc.description.abstractThe present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.titleMicro-RNA family that modulates fibrosis and uses thereof
dc.typePatent
dc.description.departmentBoard of Regents, University of Texas System
dc.rights.restrictionOpen
dc.contributor.assigneeBoard of Regents, Univ. of Tex. Sys.
dc.date.filed2015-01-27
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dc.identifier.patentnumber8940713
dc.identifier.applicationnumber13840896
dc.subject.uspc514/44A


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