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Isolation of binding proteins with high affinity to ligands
(United States Patent and Trademark Office, 2006-08-01)
The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via “display-less” library screening. In the technique, ...
Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
(United States Patent and Trademark Office, 2000-07-04)
Disclosed are methods and compositions for producing heterologous disulfide bond containing polypeptides in bacterial cells. In preferred embodiments the methods involve co-expression of a prokaryotic disulfide isomerase, ...
High throughput sequencing of multiple transcripts
(United States Patent and Trademark Office, 2017-07-18)
The present disclosure generally relates to sequencing two or more genes expressed in a single cell in a high-throughput manner. More particularly, the present disclosure relates to a method for high-throughput sequencing ...
Recombinant antibodies for the detection and neutralization of anthrax toxin
(United States Patent and Trademark Office, 2008-11-04)
A composition and method for treating a host having or at risk of infection by Bacillus anthracis using an affinity matured antibody or portion thereof derived from a monoclonal antibody.
Prokaryotic host cells for expressing proteins rich in disulfide bonds
(United States Patent and Trademark Office, 2010-10-19)
The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor ...
Antibodies with increased affinities for anthrax antigens
(United States Patent and Trademark Office, 2005-07-12)
The invention overcomes the deficiencies of the prior art by providing antibody compositions having improved affinities for Bacillus anthracis antigens. The compositions have important thereapeutic and diagnostic applications, ...
Engineered primate L-methioninase for therapeutic purposes
(United States Patent and Trademark Office, 2016-11-01)
Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase ...
Selection of bacterial inner-membrane anchor polypeptides
(United States Patent and Trademark Office, 2009-11-03)
The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating polypeptides capable of anchoring heterologous polypeptides to a bacterial inner membrane. In the technique, libraries ...
Constitutive soluble methane monooxygenase mutants of methanotrophic bacteria such as Methylosinus trichosporium A.T.C.C. 55314
(United States Patent and Trademark Office, 1994-05-31)
Selection of mutant methanotrophic bacteria capable of efficiently degrading halogenated hydrocarbons typically found in numerous wastewater sources is described. The mutants are distinguishable from parental strains in ...
Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides
(United States Patent and Trademark Office, 1993-11-23)
The invention relates to the construction of protease-deficient Escherichia coli hosts which when combined with an expression system are useful for the production of proteolytically sensitive polypeptides. The invention ...