Now showing items 1-3 of 3
Micro-RNA family that modulates fibrosis and uses thereof
(United States Patent and Trademark Office, 2013-05-14)
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated ...
Micro-RNAs that control myosin expression and myofiber identity
(United States Patent and Trademark Office, 2013-07-09)
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast ...
Micro-RNAS of the MIR-15 family modulate cardiomyocyte survival and cardiac repair
(United States Patent and Trademark Office, 2013-08-20)
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, ...