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dc.contributorVisweswariah, Sandhya
dc.creatorKashiparekh, Anokhi
dc.date.accessioned2018-09-18T14:21:32Z
dc.date.available2018-09-18T14:21:32Z
dc.date.issued2017
dc.identifierdoi:10.15781/T25T3GJ5D
dc.identifier.urihttp://hdl.handle.net/2152/68463
dc.descriptionIn recent years, Drosophila melanogaster has emerged as an important model in understanding genetic systems and molecular pathways. This can be attributed to the presence of approximately 75% functional homologues of human disease causing genes. One such case is the WAGR syndrome, a genetic condition affecting children, making them more prone to Wilms tumor, Aniridia, Genitourinary abnormalities, and Retardation. Human genes MPPED1 and MPPED2, associated with this syndrome, have a single ortholog in the Drosophila genome, CG16717. This study examined the role of CG16717 in D. melanogaster upon infliction with a biotic stressor. Knockout, rescue, and overexpressor mated lines were created and maintained at 20ºC. They were infected orally and systemically with Erwinia caratova caratova 15, a gram negative bacteria, and were monitored twice a day. Survival analysis showed that among treatment groups, knockouts survived the least median days while the overexpressors surpassed the wild control in lifespan. The presence of CG16717 can be seen regulating the immune response and consequently improving the lifespan of the Drosophila melanogaster flies.en_US
dc.language.isoengen_US
dc.relation.ispartofResearch Weeken_US
dc.subjectgeneticsen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectimmunityen_US
dc.subjectCG16717en_US
dc.titleThe Role of CG16717 in Drosophila melanogaster immunityen_US
dc.typePosteren_US
dc.description.departmentMolecular Biosciencesen_US
dc.rights.restrictionOpenen_US


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