The Role of CG16717 in Drosophila melanogaster immunity
MetadataShow full item record
In recent years, Drosophila melanogaster has emerged as an important model in understanding genetic systems and molecular pathways. This can be attributed to the presence of approximately 75% functional homologues of human disease causing genes. One such case is the WAGR syndrome, a genetic condition affecting children, making them more prone to Wilms tumor, Aniridia, Genitourinary abnormalities, and Retardation. Human genes MPPED1 and MPPED2, associated with this syndrome, have a single ortholog in the Drosophila genome, CG16717. This study examined the role of CG16717 in D. melanogaster upon infliction with a biotic stressor. Knockout, rescue, and overexpressor mated lines were created and maintained at 20ºC. They were infected orally and systemically with Erwinia caratova caratova 15, a gram negative bacteria, and were monitored twice a day. Survival analysis showed that among treatment groups, knockouts survived the least median days while the overexpressors surpassed the wild control in lifespan. The presence of CG16717 can be seen regulating the immune response and consequently improving the lifespan of the Drosophila melanogaster flies.