New developments in texaphyrin chemistry
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Dr. Sessler et al. first synthesized Texaphyrin in the 1980s. Since then, this expanded porphyrin has been at the forefront of the Sessler group’s research. Although decades worth of effort has been devoted to exploring texaphyrin and its derivatives, there still remain unexplored avenues of research related to the unique properties of this macrocyclic ligand. The work detailed in this thesis reflects an attempt to bring a fresh look into the world of texaphyrin chemistry. Chapter 1 of this thesis briefly delves into the background of texaphyrin. In Chapter 2, the synthesis of an MRI (magnetic resonance imaging) active derivative of texaphyrin is detailed. In Chapter 3, is discussed the synthesis and characterization of a Dy(III)-texaphyrin derivative that was studied for its potential as a single molecule magnet (SMM). Chapter 4 focuses on trying to improve the toxicity of well-known anticancer compounds through co-incubation with MGd, while Chapter 5 details the synthetic attempts to prepare a new Pt(II)-based Gd(III)-texaphyrin anticancer conjugate.
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Jonathan L. Sessler; Gregory W. Hemmi; Tarak D. Mody; Vladimir A. Kral; Darren Magda (United States Patent and Trademark Office, 1997-05-27)Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to ...
Richard E. Thomas; Jonathan L. Sessler; Brent L. Iverson; Vladimir A. Kral; Daniel A. Smith; Darren Magda (United States Patent and Trademark Office, 1997-01-14)The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. Described are ...
Jonathan L. Sessler; Gregory W. Hemmi; Tarak D. Mody (United States Patent and Trademark Office, 1997-02-04)Texaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or ...