Development of transition metal catalyzed carbon-carbon bond forming reactions with abundant or scarce chemicals
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The development of more efficient carbon-carbon bond transformation is of great significance. One of the more common approaches to forging carbon-carbon bonds is the addition of carbon- based nucleophiles to carbonyl compounds, exploiting classical electrophile-nucleophile pairing. In an effort to minimize nucleophile pre-activation and organometallic byproducts, my research in the Krische group focuses on the development of efficient methods for the in-situ formation of alkyl-metal nucleophiles from π- unsaturated compounds via transition metal catalysis. With the use of Ruthenium or Osmium we can use readily abundant a-olefins such as ethylene gas and couple it with various secondary alcohols via transfer hydrogenative C-C coupling in a proposed oxidative coupling pathway.