• Asymmetry and Inequity in the Inheritance of a Bacterial Adhesive 

    Cooley, Benjamin J.; Dellos-Nolan, Sheri; Dhamani, Numa; Todd, Ross; Waller, William; Wozniak, Daniel; Gordon, Vernita D. (New Journal of Physics, 2016-04)
    Pseudomonas aeruginosa is an opportunistic human pathogen that forms biofilm infections in a wide variety of contexts. Biofilms initiate when bacteria attach to a surface, which triggers changes in gene expression leading ...
  • Bacteria Use Type IV Pili to Walk Upright and Detach from Surfaces 

    Gibiansky, Maxsim L.; Conrad, Jacinta C.; Jin, Fan; Gordon, Vernita D.; Motto, Dominick A.; Mathewson, Margie A. (Science, 2010-10)
    Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition ...
  • A Dynamical Systems Approach to Spiral Wave Dynamics 

    Barkley, Dwight; Kevrekidis, Ioannis G. (1994-09)
    A simple system of five nonlinear ordinary differential equations is shown to reproduce many dynamical features of spiral waves in two-dimensional excitable media.
  • Lagrangian Based Methods for Coherent Structure Detection 

    Allshouse, Michael R.; Peacock, Thomas (2015-09)
    There has been a proliferation in the development of Lagrangian analytical methods for detecting coherent structures in fluid flow transport, yielding a variety of qualitatively different approaches. We present a review ...
  • A Low-Cost, Hands-on Module to Characterize Antimicrobial Compounds Using an Interdisciplinary, Biophysical Approach 

    Kaushik, Karishma S.; Kessel, Ashley; Ratnayeke, Nalin; Gordon, Vernita D. (PLoS Biology, 2015-01)
    We have developed a hands-on experimental module that combines biology experiments with a physics-based analytical model in order to characterize antimicrobial compounds. To understand antibiotic resistance, participants ...
  • Membrane Adhesion and the Formation of Heterogeneities: Biology, Biophysics, and Biotechnology 

    Gordon, Vernita D.; O'Halloran, T. J.; Shindell, O. (Physical Chemistry Chemical Physics, 2015-03)
    Membrane adhesion is essential to many vital biological processes. Sites of membrane adhesion are often associated with heterogeneities in the lipid and protein composition of the membrane. These heterogeneities are thought ...
  • The Pseudomonas Aeruginosa PSL Polysaccharide is a Social but Non-Cheatable Trait in Biofilms 

    Irie, Yasuhiko; Roberts, Aled E. L.; Kragh, Kasper N.; Gordon, Vernita D.; Hutchison, Jamie; Allen, Rosalind J.; Bjarnsholt, Thomas; West, Stuart A.; Diggle, Stephen P. (bioRxiv, 2016-05)
    Extracellular polysaccharides are compounds secreted by microorganisms into the surrounding environment and which are important for surface attachment and maintaining structural integrity within biofilms. They have been ...
  • Refining Finite-Time Lyapunov Exponent Ridges and the Challenges of Classifying Them 

    Allshouse, Michael R.; Peacock, Thomas (2015-08)
    While more rigorous and sophisticated methods for identifying Lagrangian based coherent structures exist, the finite-time Lyapunov exponent (FTLE) field remains a straightforward and popular method for gaining some insight ...
  • Rhombic Patterns: Broken Hexagonal Symmetry 

    Ouyang, Qi; Gunaratne, Gemunu H.; Swinney, Harry L. (1993-10)
    Landau-Ginzburg equations derived to conserve two-dimensional spatial symmetries lead to the prediction that rhombic arrays with characteristic angles slightly differ from 60 degrees should form in many systems. Beyond the ...
  • Role of Multicellular Aggregates in Biofilm Formation 

    Kragh, Kasper N.; Hutchison, Jaime B.; Melaugh, Gavin; Rodesney, Chris; Roberts, Aled E. L.; Irie, Yasuhiko; Jensen, Peter O.; Diggle, Stephen P.; Allen, Rosalind J.; Gordon, Vernita D.; Bjarnsholt, Thomas (American Society for Microbiology, 2016-03)
    In traditional models of in vitro biofilm development, individual bacterial cells seed a surface, multiply, and mature into multicellular, three-dimensional structures. Much research has been devoted to elucidating the ...
  • Shaping the Growth Behaviour of Biofilms Initiated from Bacterial Aggregates 

    Melaugh, Gavin; Hutchison, Jamie; Kragh, Kasper N.; Irie, Yasuhiko; Roberts, Aled E. L.; Bjarnsholt, Thomas; Diggle, Stephen P.; Gordon, Vernita D.; Allen, Rosalind J. (PLoS ONE, 2016-03)
    Bacterial biofilms are usually assumed to originate from individual cells deposited on a surface. However, many biofilm-forming bacteria tend to aggregate in the planktonic phase so that it is possible that many natural ...
  • Shiver me timbers: Pulsatile Contractility in Model Tissues 

    Gordon, Vernita D. (Proceedings of the National Academy of Sciences of the U. S. A., 2011-08)
    Cells self-assemble and differentiate to form functional structures. This theme is ubiquitous throughout multicellular life and happens all along an organism's lifespan, from embryogenesis to tissue maintenance in a mature ...
  • Singly Flagellated Pseudomonas Aeruginosa Chemotaxes Efficiently by Unbiased Motor Regulation 

    Cai, Qiuxian; Li, Zhaojun; Ouyang, Qi; Gordon, Vernita D. (American Society for Microbiology, 2016-04)
    Pseudomonas aeruginosa is an opportunistic human pathogen that has long been known to chemotax. More recently, it has been established that chemotaxis is an important factor in the ability of P. aeruginosa to make biofilms. ...
  • Solid-Like Domains in Mixed Lipid Bilayers: Effect of Membrane Lamellarity and Transition Pathway 

    Gordon, Vernita D.; Beales, Paul A.; Shearman, Gemma C.; Zhao, Zhijun; Seddon, John M.; Poon, Wilson C. K.; Egelhaaf, Stefan U. (Advances in Planar Lipid Bilayers and Liposomes, 2014)
    We present optical observations of phase separation in mixed model membranes in the form of giant unilamellar vesicles. These observations are compared to the phase behavior of lipid mixtures, which we determined by X-ray ...
  • Specific Adhesion of Membranes Simultaneously Supports Dual Heterogeneities in Lipids and Proteins 

    Shindell, O.; Mica, N.; Ritzer, M.; Gordon, Vernita D. (Physical Chemistry Chemical Physics, 2015-03)
    Membrane adhesion is a vital component of many biological processes. Heterogeneities in lipid and protein composition are often associated with the adhesion site. These heterogeneities are thought to play functional roles ...
  • Specific Adhesion of Membranes Simultaneously Supports Dual Heterogeneities in Lipids and Proteins 

    Shindell, O.; Mica, N.; Ritzer, M.; Gordon, Vernita D. (Physical Chemistry Chemical Physics, 2015-03)
    Membrane adhesion is a vital component of many biological processes. Heterogeneities in lipid and protein composition are often associated with the adhesion site. These heterogeneities are thought to play functional roles ...
  • Tobramycin and Bicarbonate Synergise to Kill Planktonic Pseudomonas Aeruginosa, but Antagonise to Promote Biofilm Survival 

    Kaushik, Karishma S.; Stolhandske, Jake; Shindell, Orrin; Smyth, Hugh D.; Gordon, Vernita D. (Nature Partner Journals, 2016-05)
    Increasing antibiotic resistance and the declining rate at which new antibiotics come into use create a need to increase the efficacy of existing antibiotics. The aminoglycoside tobramycin is standard-of-care for many types ...
  • Torque And Optical Traps 

    Ibeneche, C. (2008-12)
    Optical traps are an important tool for research in the field of single molecule biophysics. Recent advances in optical trapping have extended their functionality from simple linear manipulation and measurement of forces, ...
  • Transition to Chemical Turbulence 

    Ouyang, Q.; Swinney, Harry L. (1991-12)
    Experiments have been conducted on Turing-type chemical spatial patterns and their variants in a quasi-two-dimensional open spatial reactor with a chlorite-iodide-malonic acid reaction. A variety of stationary spatial ...