Synthesis and metallation of a novel anthracene ligand architecture for development of structural models of mono [Fe]-hydrogenase
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Herein reported is the design and synthesis of a novel ligand architecture for the development of synthetic model complexes of mono–[Fe] hydrogenase. The ligand utilizes a functionalized anthracene scaffold that spatially directs fac-coordination of the CNHNpySthiol donors characteristic of the active site. Metallation of the ligand was performed with [Fe(CO)4Br2] in the absence and presence of various bases in order to develop iron dicarbonyl complexes of relevance to the active site of mono–[Fe] hydrogenase. The choice of base serves an important role in mediating reactivity and affords different complexes as evidenced by IR spectroscopy.