• Login
    • Submit
    View Item 
    •   Repository Home
    • UT Electronic Theses and Dissertations
    • UT Electronic Theses and Dissertations
    • View Item
    • Repository Home
    • UT Electronic Theses and Dissertations
    • UT Electronic Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Nanoparticle margination, adhesion, and uptake in microflow

    Icon
    View/Open
    JURNEY-DISSERTATION-2015.pdf (3.664Mb)
    Date
    2015-08
    Author
    Jurney, Patrick Levi
    Share
     Facebook
     Twitter
     LinkedIn
    Metadata
    Show full item record
    Abstract
    Various nanoparticles have been investigated as drug carriers for delivery to diseased cells in the body. Targeted delivery of nanocarriers specifically to diseased cells can help to shield collateral cells from harmful cytotoxic drugs and reduce the many harmful side effects associated with chemotherapy. Recent advancements in our understanding of the complex behavior of intravenously injected nanoparticles has informed the rational design of the next generation of tailored nanocarriers. However fundamental questions about the mechanisms driving the behavior of nanoparticles in vasculature remain. Phenomena important for particle margination, adhesion, and uptake as well as the dependence of each on nanoparticle characteristics such as size and shape still remain elusive. This dissertation reports an experimental study of the effects of size and shape on polymeric nanoparticle margination and uptake in bare and cell-containing microfluidic environments, respectively. It is found that the competition of Brownian force and electrostatic repulsive forces between particles near the wall and adhered particles on a bare glass substrate lead to insensitive size dependence of spherical particles on margination and adhesion propensity. With the presence of cells on channel walls and a reduced zeta potential, however, the repulsive force is reduced such that a dominant Brownian force leads to more uptake of smaller spherical particles in shear-adapted endothelial cells. In comparison, increased flow-driven rotation of non-spherical nanoparticles with increased size and aspect ratio enhances particle/cell interaction frequency which dominates the effect of Brownian motion and the energy for membrane deformation, leading to more uptake of larger and larger-aspect ratio non-spherical nanoparticles in shear adapted endothelial cells.
    Subject
    Nanoparticle drug delivery
    Microfluidics
    Margination
    URI
    http://hdl.handle.net/2152/43948
    Collections
    • UT Electronic Theses and Dissertations
    University of Texas at Austin Libraries
    • facebook
    • twitter
    • instagram
    • youtube
    • CONTACT US
    • MAPS & DIRECTIONS
    • JOB OPPORTUNITIES
    • UT Austin Home
    • Emergency Information
    • Site Policies
    • Web Accessibility Policy
    • Web Privacy Policy
    • Adobe Reader
    Subscribe to our NewsletterGive to the Libraries

    © The University of Texas at Austin

    Browse

    Entire RepositoryCommunities & CollectionsDate IssuedAuthorsTitlesSubjectsDepartmentThis CollectionDate IssuedAuthorsTitlesSubjectsDepartment

    My Account

    Login

    Information

    AboutContactPoliciesGetting StartedGlossaryHelpFAQs

    Statistics

    View Usage Statistics
    University of Texas at Austin Libraries
    • facebook
    • twitter
    • instagram
    • youtube
    • CONTACT US
    • MAPS & DIRECTIONS
    • JOB OPPORTUNITIES
    • UT Austin Home
    • Emergency Information
    • Site Policies
    • Web Accessibility Policy
    • Web Privacy Policy
    • Adobe Reader
    Subscribe to our NewsletterGive to the Libraries

    © The University of Texas at Austin