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dc.contributor.advisorKoeller, Jim
dc.contributor.advisorSaklad, Stephen R.
dc.creatorPan, Isaac
dc.date.accessioned2016-10-31T14:59:16Z
dc.date.available2016-10-31T14:59:16Z
dc.date.issued2016-08
dc.date.submittedAugust 2016
dc.identifierdoi:10.15781/T2NV99D5H
dc.identifier.urihttp://hdl.handle.net/2152/43380
dc.description.abstractBackground: Use of first-generation antipsychotics (FGAs) has been largely replaced by second-generation antipsychotics (SGAs) in the United States (US) due to the lower risk of extrapyramidal symptoms (EPS) associated with SGAs. However, SGAs have higher risk of metabolic adverse effects than FGAs do, and some SGA agents have higher metabolic risk than the other SGA agents. Historically, patients of racial/ethnic minorities were less likely than those of non-Hispanic White (NHW) to receive adequate mental health care. Our investigation sought to identify if there is an association between the patient race/ethnicity (NHW or ‘Others') and the receipt of lower-metabolic-risk SGAs (LMRS) or higher-metabolic-risk SGAs (HMRS) in the outpatient settings. Methods: This was a retrospective study using the nationally representative data from the Medical Expenditure Panel Survey from 2008 to 2013. The chi-square test was used to determine the relationship between race/ethnicity (NHW or ‘Others’) and the receipt of LMRS or HMRS. Results: From 2008 to 2013, we estimated about 4 million patients using SGAs per year. Approximately 2.8 million patients were NHW, and 1.2 million patients were ‘Others’. Approximately 29.7% (1.2 million) used LMRS, and 70.3% (2.8 million) used HMRS. The disproportionate use of LMRS and HMRS was significant between races/ethnicities. More patients of NHW received LMRS than those of ‘Others’ (p = 0.021), and less patients of NHW received HMRS than those of ‘Others’ (p = 0.021). Conclusion: With our 2-group categorization of LMRS and HMRS, there appeared to be a racial/ethnic disparity in the receipt of LMRS. Patients of racial/ethnic minorities were less likely to receive LMRS than those of NHW.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.subjectAntipsychotic
dc.subjectDisparity
dc.titleAssociation between race/ethnicity and the receipt of outpatient second-generation antipsychotic agents stratified by metabolic effects
dc.typeThesis
dc.date.updated2016-10-31T14:59:17Z
dc.contributor.committeeMemberReveles, Kelly R
dc.contributor.committeeMemberGutierrez, Cynthia A
dc.description.departmentPharmacy
thesis.degree.departmentPharmacy
thesis.degree.disciplinePharmaceutical sciences
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Pharmaceutical Sciences
dc.creator.orcid0000-0003-2371-7963
dc.type.materialtext


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